Gene information
Official symbol IL12B
Official full name interleukin 12B
Gene type protein-coding gene
Chromosome5q33.3
Alias symbolCLMF|IL-12B|NKSF|CLMF2
Previous symbolNKSF2
Gene familyImmunoglobulin like domain containing|Interleukins
Resources
Entrez Gene 3593
HGNC HGNC:5970
Ensembl ENSG00000113302
Vega OTTHUMG00000130307
UCSC uc003lxr.2
GO terms: 212 records
GO Description Category LogP Number of genes Detail
GO:0001562 response to protozoan GO Biological Processes -4.01585848 7 More
GO:0001775 cell activation GO Biological Processes -43.3738118 71 More
GO:0001818 negative regulation of cytokine production GO Biological Processes -48.9957481 97 More
GO:0001819 positive regulation of cytokine production GO Biological Processes -44.1872667 64 More
GO:0001910 regulation of leukocyte mediated cytotoxicity GO Biological Processes -7.82450130 11 More
GO:0001912 positive regulation of leukocyte mediated cytotoxicity GO Biological Processes -3.17989306 9 More
GO:0001914 regulation of T cell mediated cytotoxicity GO Biological Processes -2.74076564 4 More
GO:0001934 positive regulation of protein phosphorylation GO Biological Processes -52.8272623 84 More
GO:0001936 regulation of endothelial cell proliferation GO Biological Processes -54.5504306 75 More
GO:0002230 positive regulation of defense response to virus by host GO Biological Processes -2.11862029 3 More
GO:0002237 response to molecule of bacterial origin GO Biological Processes -48.4964960 93 More
GO:0002250 adaptive immune response GO Biological Processes -8.22919489 29 More
GO:0002252 immune effector process GO Biological Processes -24.2648770 43 More
GO:0002263 cell activation involved in immune response GO Biological Processes -10.3401505 18 More
GO:0002285 lymphocyte activation involved in immune response GO Biological Processes -7.04246662 12 More
GO:0002286 T cell activation involved in immune response GO Biological Processes -5.33688125 8 More
GO:0002287 alpha-beta T cell activation involved in immune response GO Biological Processes -5.32260704 6 More
GO:0002292 T cell differentiation involved in immune response GO Biological Processes -5.02945267 6 More
GO:0002293 alpha-beta T cell differentiation involved in immune response GO Biological Processes -5.32260704 6 More
GO:0002294 CD4-positive, alpha-beta T cell differentiation involved in immune response GO Biological Processes -5.40213264 6 More
GO:0002366 leukocyte activation involved in immune response GO Biological Processes -10.4998832 18 More
GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO Biological Processes -11.9339394 22 More
GO:0002520 immune system development GO Biological Processes -15.2957169 80 More
GO:0002521 leukocyte differentiation GO Biological Processes -12.4650129 27 More
GO:0002683 negative regulation of immune system process GO Biological Processes -26.6415063 77 More
GO:0002694 regulation of leukocyte activation GO Biological Processes -32.0887020 60 More
GO:0002696 positive regulation of leukocyte activation GO Biological Processes -27.9249645 47 More
GO:0002697 regulation of immune effector process GO Biological Processes -33.2683521 48 More
GO:0002699 positive regulation of immune effector process GO Biological Processes -18.3926498 29 More
GO:0002705 positive regulation of leukocyte mediated immunity GO Biological Processes -8.38274670 14 More
GO:0002706 regulation of lymphocyte mediated immunity GO Biological Processes -13.7265777 21 More
GO:0002708 positive regulation of lymphocyte mediated immunity GO Biological Processes -8.31079168 13 More
GO:0002709 regulation of T cell mediated immunity GO Biological Processes -8.74858930 12 More
GO:0002711 positive regulation of T cell mediated immunity GO Biological Processes -6.00483593 8 More
GO:0002715 regulation of natural killer cell mediated immunity GO Biological Processes -3.31185110 5 More
GO:0002717 positive regulation of natural killer cell mediated immunity GO Biological Processes -2.08003997 3 More
GO:0002761 regulation of myeloid leukocyte differentiation GO Biological Processes -12.4818724 17 More
GO:0002763 positive regulation of myeloid leukocyte differentiation GO Biological Processes -8.56410954 10 More
GO:0002819 regulation of adaptive immune response GO Biological Processes -16.0189388 24 More
GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO Biological Processes -14.6775052 22 More
GO:0002831 regulation of response to biotic stimulus GO Biological Processes -10.931136 25 More
GO:0002833 positive regulation of response to biotic stimulus GO Biological Processes -5.95822718 13 More
GO:0002861 regulation of inflammatory response to antigenic stimulus GO Biological Processes -5.72585157 11 More
GO:0002862 negative regulation of inflammatory response to antigenic stimulus GO Biological Processes -3.60825621 7 More
GO:0004896 cytokine receptor activity GO Molecular Functions -9.30297759 21 More
GO:0005125 cytokine activity GO Molecular Functions -54.7097150 57 More
GO:0005126 cytokine receptor binding GO Molecular Functions -41.4908940 50 More
GO:0005770 late endosome GO Cellular Components -2.28850711 22 More
GO:0005788 endoplasmic reticulum lumen GO Cellular Components -47.2996164 57 More
GO:0008083 growth factor activity GO Molecular Functions -26.3260872 31 More
GO:0008283 cell population proliferation GO Biological Processes -17.2298624 68 More
GO:0008285 negative regulation of cell population proliferation GO Biological Processes -53.5569125 147 More
GO:0009314 response to radiation GO Biological Processes -9.77450393 26 More
GO:0009411 response to UV GO Biological Processes -7.07745319 13 More
GO:0009416 response to light stimulus GO Biological Processes -4.81054429 15 More
GO:0009615 response to virus GO Biological Processes -11.2861143 47 More
GO:0009617 response to bacterium GO Biological Processes -52.1760880 83 More
GO:0010224 response to UV-B GO Biological Processes -2.96024730 3 More
GO:0010453 regulation of cell fate commitment GO Biological Processes -3.57905448 8 More
GO:0010533 regulation of activation of Janus kinase activity GO Biological Processes -5.46227840 4 More
GO:0010536 positive regulation of activation of Janus kinase activity GO Biological Processes -6.00954872 4 More
GO:0010660 regulation of muscle cell apoptotic process GO Biological Processes -26.1774267 35 More
GO:0010661 positive regulation of muscle cell apoptotic process GO Biological Processes -13.2907676 16 More
GO:0010942 positive regulation of cell death GO Biological Processes -48.7037743 123 More
GO:0019221 cytokine-mediated signaling pathway GO Biological Processes -27.5840932 43 More
GO:0019233 sensory perception of pain GO Biological Processes -10.7642352 20 More
GO:0019955 cytokine binding GO Molecular Functions -19.1485102 24 More
GO:0022407 regulation of cell-cell adhesion GO Biological Processes -32.4337382 53 More
GO:0022409 positive regulation of cell-cell adhesion GO Biological Processes -25.7751074 39 More
GO:0030097 hemopoiesis GO Biological Processes -14.1443585 71 More
GO:0030098 lymphocyte differentiation GO Biological Processes -7.22308617 17 More
GO:0030101 natural killer cell activation GO Biological Processes -1.32158811 3 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030217 T cell differentiation GO Biological Processes -5.22709721 11 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0031341 regulation of cell killing GO Biological Processes -10.2641102 14 More
GO:0031343 positive regulation of cell killing GO Biological Processes -3.44182824 10 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031348 negative regulation of defense response GO Biological Processes -30.3795513 65 More
GO:0031349 positive regulation of defense response GO Biological Processes -32.1301903 71 More
GO:0031904 endosome lumen GO Cellular Components -9.27147512 9 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0032496 response to lipopolysaccharide GO Biological Processes -45.257773 87 More
GO:0032645 regulation of granulocyte macrophage colony-stimulating factor production GO Biological Processes -2.80517019 3 More
GO:0032649 regulation of interferon-gamma production GO Biological Processes -12.4733429 27 More
GO:0032653 regulation of interleukin-10 production GO Biological Processes -10.1959901 18 More
GO:0032655 regulation of interleukin-12 production GO Biological Processes -15.9447313 16 More
GO:0032660 regulation of interleukin-17 production GO Biological Processes -6.79373102 8 More
GO:0032680 regulation of tumor necrosis factor production GO Biological Processes -32.0729913 56 More
GO:0032693 negative regulation of interleukin-10 production GO Biological Processes -2.63397233 5 More
GO:0032700 negative regulation of interleukin-17 production GO Biological Processes -3.75695916 4 More
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production GO Biological Processes -3.04620727 3 More
GO:0032733 positive regulation of interleukin-10 production GO Biological Processes -8.60591296 9 More
GO:0032735 positive regulation of interleukin-12 production GO Biological Processes -12.7826256 12 More
GO:0032740 positive regulation of interleukin-17 production GO Biological Processes -4.70812216 5 More
GO:0032760 positive regulation of tumor necrosis factor production GO Biological Processes -21.1788990 23 More
GO:0032814 regulation of natural killer cell activation GO Biological Processes -6.02130395 7 More
GO:0032816 positive regulation of natural killer cell activation GO Biological Processes -3.53254248 4 More
GO:0032944 regulation of mononuclear cell proliferation GO Biological Processes -24.6915018 34 More
GO:0032946 positive regulation of mononuclear cell proliferation GO Biological Processes -20.2231223 25 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0034103 regulation of tissue remodeling GO Biological Processes -21.5631413 32 More
GO:0034341 response to interferon-gamma GO Biological Processes -10.8524889 26 More
GO:0034391 regulation of smooth muscle cell apoptotic process GO Biological Processes -12.4801943 15 More
GO:0034393 positive regulation of smooth muscle cell apoptotic process GO Biological Processes -5.72938190 7 More
GO:0035710 CD4-positive, alpha-beta T cell activation GO Biological Processes -4.53716649 6 More
GO:0042088 T-helper 1 type immune response GO Biological Processes -3.92689699 4 More
GO:0042093 T-helper cell differentiation GO Biological Processes -5.40213264 6 More
GO:0042102 positive regulation of T cell proliferation GO Biological Processes -13.4787271 17 More
GO:0042104 positive regulation of activated T cell proliferation GO Biological Processes -7.12111476 7 More
GO:0042110 T cell activation GO Biological Processes -7.78997285 18 More
GO:0042129 regulation of T cell proliferation GO Biological Processes -18.0871480 25 More
GO:0042269 regulation of natural killer cell mediated cytotoxicity GO Biological Processes -3.48241215 5 More
GO:0042509 regulation of tyrosine phosphorylation of STAT protein GO Biological Processes -19.4049069 20 More
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO Biological Processes -19.8380655 19 More
GO:0042742 defense response to bacterium GO Biological Processes -25.9215771 41 More
GO:0042832 defense response to protozoan GO Biological Processes -4.13020121 7 More
GO:0043065 positive regulation of apoptotic process GO Biological Processes -46.1285536 112 More
GO:0043068 positive regulation of programmed cell death GO Biological Processes -46.5713594 114 More
GO:0043367 CD4-positive, alpha-beta T cell differentiation GO Biological Processes -4.83197184 6 More
GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation GO Biological Processes -5.90313372 12 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0045088 regulation of innate immune response GO Biological Processes -6.98001665 16 More
GO:0045089 positive regulation of innate immune response GO Biological Processes -3.90916833 9 More
GO:0045321 leukocyte activation GO Biological Processes -25.4958219 48 More
GO:0045580 regulation of T cell differentiation GO Biological Processes -7.18541630 25 More
GO:0045619 regulation of lymphocyte differentiation GO Biological Processes -8.78322888 17 More
GO:0045621 positive regulation of lymphocyte differentiation GO Biological Processes -6.96534841 12 More
GO:0045622 regulation of T-helper cell differentiation GO Biological Processes -5.35296451 10 More
GO:0045637 regulation of myeloid cell differentiation GO Biological Processes -9.39364926 18 More
GO:0045639 positive regulation of myeloid cell differentiation GO Biological Processes -7.07849207 11 More
GO:0045670 regulation of osteoclast differentiation GO Biological Processes -10.2566667 12 More
GO:0045672 positive regulation of osteoclast differentiation GO Biological Processes -7.61299657 7 More
GO:0045785 positive regulation of cell adhesion GO Biological Processes -29.6368249 50 More
GO:0045859 regulation of protein kinase activity GO Biological Processes -34.3615088 109 More
GO:0045860 positive regulation of protein kinase activity GO Biological Processes -29.3929160 47 More
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity GO Biological Processes -2.28850890 3 More
GO:0046006 regulation of activated T cell proliferation GO Biological Processes -6.86981007 8 More
GO:0046631 alpha-beta T cell activation GO Biological Processes -4.13140497 7 More
GO:0046632 alpha-beta T cell differentiation GO Biological Processes -3.95887136 6 More
GO:0046637 regulation of alpha-beta T cell differentiation GO Biological Processes -6.05306731 14 More
GO:0046649 lymphocyte activation GO Biological Processes -10.1732143 26 More
GO:0046982 protein heterodimerization activity GO Molecular Functions -2.81006698 12 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0048534 hematopoietic or lymphoid organ development GO Biological Processes -16.4041704 79 More
GO:0048660 regulation of smooth muscle cell proliferation GO Biological Processes -48.6624498 69 More
GO:0048662 negative regulation of smooth muscle cell proliferation GO Biological Processes -21.7509412 30 More
GO:0050670 regulation of lymphocyte proliferation GO Biological Processes -22.6006415 32 More
GO:0050671 positive regulation of lymphocyte proliferation GO Biological Processes -19.1485102 24 More
GO:0050678 regulation of epithelial cell proliferation GO Biological Processes -51.9930445 102 More
GO:0050680 negative regulation of epithelial cell proliferation GO Biological Processes -26.5961536 48 More
GO:0050688 regulation of defense response to virus GO Biological Processes -1.79095362 4 More
GO:0050691 regulation of defense response to virus by host GO Biological Processes -2.66162124 4 More
GO:0050708 regulation of protein secretion GO Biological Processes -30.3716714 63 More
GO:0050709 negative regulation of protein secretion GO Biological Processes -12.5236372 21 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050728 negative regulation of inflammatory response GO Biological Processes -31.0556128 55 More
GO:0050729 positive regulation of inflammatory response GO Biological Processes -38.1621935 57 More
GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO Biological Processes -27.1120967 60 More
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO Biological Processes -27.9747849 34 More
GO:0050777 negative regulation of immune response GO Biological Processes -11.1440698 32 More
GO:0050778 positive regulation of immune response GO Biological Processes -17.2528761 40 More
GO:0050829 defense response to Gram-negative bacterium GO Biological Processes -15.0142277 17 More
GO:0050863 regulation of T cell activation GO Biological Processes -20.3209154 36 More
GO:0050865 regulation of cell activation GO Biological Processes -40.6877761 71 More
GO:0050867 positive regulation of cell activation GO Biological Processes -31.2431659 51 More
GO:0050870 positive regulation of T cell activation GO Biological Processes -17.6497748 28 More
GO:0051046 regulation of secretion GO Biological Processes -54.0079540 130 More
GO:0051048 negative regulation of secretion GO Biological Processes -20.2278199 42 More
GO:0051051 negative regulation of transport GO Biological Processes -46.8709407 107 More
GO:0051133 regulation of NK T cell activation GO Biological Processes -3.46984057 3 More
GO:0051135 positive regulation of NK T cell activation GO Biological Processes -3.75458174 3 More
GO:0051223 regulation of protein transport GO Biological Processes -25.2801266 81 More
GO:0051224 negative regulation of protein transport GO Biological Processes -11.0190941 26 More
GO:0051249 regulation of lymphocyte activation GO Biological Processes -22.6120519 46 More
GO:0051251 positive regulation of lymphocyte activation GO Biological Processes -20.2181987 37 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0051607 defense response to virus GO Biological Processes -3.02916189 22 More
GO:0070201 regulation of establishment of protein localization GO Biological Processes -24.4831554 82 More
GO:0070663 regulation of leukocyte proliferation GO Biological Processes -26.8242532 37 More
GO:0070665 positive regulation of leukocyte proliferation GO Biological Processes -21.5362473 27 More
GO:0070851 growth factor receptor binding GO Molecular Functions -16.9609899 22 More
GO:0071216 cellular response to biotic stimulus GO Biological Processes -28.1549742 59 More
GO:0071219 cellular response to molecule of bacterial origin GO Biological Processes -28.3848077 56 More
GO:0071222 cellular response to lipopolysaccharide GO Biological Processes -26.0381191 52 More
GO:0071345 cellular response to cytokine stimulus GO Biological Processes -39.647808 70 More
GO:0071346 cellular response to interferon-gamma GO Biological Processes -8.94844866 13 More
GO:0071396 cellular response to lipid GO Biological Processes -37.0669488 98 More
GO:0090287 regulation of cellular response to growth factor stimulus GO Biological Processes -21.1381780 60 More
GO:0090288 negative regulation of cellular response to growth factor stimulus GO Biological Processes -9.39414218 23 More
GO:0140375 immune receptor activity GO Molecular Functions -8.53513203 25 More
GO:0140546 defense response to symbiont GO Biological Processes -3.00647654 22 More
GO:1900746 regulation of vascular endothelial growth factor signaling pathway GO Biological Processes -8.31468142 11 More
GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway GO Biological Processes -4.51852976 6 More
GO:1901224 positive regulation of NIK/NF-kappaB signaling GO Biological Processes -6.64954322 9 More
GO:1902105 regulation of leukocyte differentiation GO Biological Processes -18.8286876 32 More
GO:1902107 positive regulation of leukocyte differentiation GO Biological Processes -14.6775052 22 More
GO:1902547 regulation of cellular response to vascular endothelial growth factor stimulus GO Biological Processes -7.92453051 11 More
GO:1902548 negative regulation of cellular response to vascular endothelial growth factor stimulus GO Biological Processes -4.18483678 6 More
GO:1903037 regulation of leukocyte cell-cell adhesion GO Biological Processes -23.2079690 66 More
GO:1903039 positive regulation of leukocyte cell-cell adhesion GO Biological Processes -20.7355312 32 More
GO:1903131 mononuclear cell differentiation GO Biological Processes -9.35861236 21 More
GO:1903530 regulation of secretion by cell GO Biological Processes -45.6472055 114 More
GO:1903531 negative regulation of secretion by cell GO Biological Processes -17.4034654 36 More
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO Biological Processes -32.3948799 57 More
GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production GO Biological Processes -20.7768498 23 More
GO:1903706 regulation of hemopoiesis GO Biological Processes -16.2759166 33 More
GO:1903708 positive regulation of hemopoiesis GO Biological Processes -14.6775052 22 More
GO:1903828 negative regulation of protein localization GO Biological Processes -8.86943289 30 More
GO:1904950 negative regulation of establishment of protein localization GO Biological Processes -11.4813166 27 More
KEGG pathways: 20 records
KEGG Description Category LogP Number of genes Detail
hsa04060 Cytokine-cytokine receptor interaction KEGG Pathway -61.0014447 66 More
hsa04620 Toll-like receptor signaling pathway KEGG Pathway -11.1460554 15 More
hsa04622 RIG-I-like receptor signaling pathway KEGG Pathway -3.50554828 6 More
hsa04630 JAK-STAT signaling pathway KEGG Pathway -14.4088859 21 More
hsa04658 Th1 and Th2 cell differentiation KEGG Pathway -5.18694144 15 More
hsa04936 Alcoholic liver disease KEGG Pathway -13.3477535 19 More
hsa04940 Type I diabetes mellitus KEGG Pathway -8.40921139 9 More
hsa05133 Pertussis KEGG Pathway -13.2270528 15 More
hsa05134 Legionellosis KEGG Pathway -13.8022551 14 More
hsa05142 Chagas disease KEGG Pathway -21.3868632 23 More
hsa05143 African trypanosomiasis KEGG Pathway -18.5080428 15 More
hsa05146 Amoebiasis KEGG Pathway -14.8474637 18 More
hsa05152 Tuberculosis KEGG Pathway -14.5221547 22 More
hsa05162 Measles KEGG Pathway -4.80674483 10 More
hsa05164 Influenza A KEGG Pathway -16.0885267 23 More
hsa05171 Coronavirus disease - COVID-19 KEGG Pathway -24.8179886 34 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
hsa05205 Proteoglycans in cancer KEGG Pathway -18.5545131 27 More
hsa05330 Allograft rejection KEGG Pathway -10.3501019 10 More
hsa05417 Lipid and atherosclerosis KEGG Pathway -33.3876857 40 More
Drug-Gene interaction
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Related drugs: 5 records
Related studies: 2 records
Molecular factor Omics type Application Objective MI type Reference
interleukin-12 proteomics adverse events[prognosis (bad)] acute ST elevation myocardial infarction Belenkova Y et al. J Inflamm Res. 2015
interleukin-12 proteomics adverse events[prognosis (bad)] acute ST elevation myocardial infarction Belenkova Y et al. J Inflamm Res. 2015
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